Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern ItalyArticle Published on 2022-12-012022-11-15 Journal: Environmental research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG association B.1 Brazil circulation collected COVID-19 database detectable anti-SARS-CoV-2 antibodies downloaded emergence evaluated Evidence group highlight IgA antibodies IgG and IgM IgM individual Infection investigated Italy Laboratory lombardy measles molecular Mutation oropharyngeal swab outbreak pandemic Patient patients PCR positive positive patient producing Rash reported retrospective RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2. screened sequence sequence information Sequencing Spread strain subjects Surveillance syndrome tested Urine virus Wuhan [DOI] 10.1016/j.envres.2022.113979 PMC 바로가기
Systematic comparison of ranking aggregation methods for gene lists in experimental resultsArticle Published on 2022-10-312022-11-16 Journal: Bioinformatics [Category] COVID19(2023년), meta-analysis, SARS, [키워드] addition aggregation Algorithm Apoptosis automated Bacteria biological process Cancer Cell Characteristics code Consensus database dataset datasets disease downloaded Evaluating Features genomic data heterogeneity implementation implicated Inclusion information lack list of gene lung cancer Macrophage Meta-analysis noise level question reliability required resulting specific type Support the SARS-CoV-2 virus Variation was performed were used [DOI] 10.1093/bioinformatics/btac621 PMC 바로가기
DeepLPI: a novel deep learning-based model for protein-ligand interaction prediction for drug repurposingArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] 신약개발, [키워드] applied approved drug baseline CNN computational method COVID-19 dataset Davis downloaded drug-target interaction drugs Features high accuracy Interaction memory molecular patients predict protein-ligand interaction Research sequence target protein target protein sequence vector [DOI] 10.1038/s41598-022-23014-1 PMC 바로가기
Genomic surveillance of the Lambda SARS-CoV-2 variant in a global phylogenetic context글로벌 계통 발생학적 맥락에서 Lambda SARS-CoV-2 변이체의 게놈 감시Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis carried clade coronavirus country detect determine downloaded Endemic epidemiologically Europe genomic Genomic surveillance GISAID GISAID database identify isolate Lambda Lineage Local local outbreak local outbreaks local outbreaks.. North America occurred Pandemics past Phylogenetic Phylogenetic analysis Phylogenetic relationship prevalent SARS-CoV-2 SARS-CoV-2 variant sequence Sequencing severe acute respiratory syndrome Coronavirus South America spike spike mutation spike mutations Spread Surveillance variant variants of concern virus [DOI] 10.1002/jmv.27889 PMC 바로가기 [Article Type] Article
Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19Article Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] 24 hour acute respiratory syndrome aged neutrophils analyses bidirectional children Clustering comparable Control controls coronavirus COVID-19 Critical demonstrated downloaded dysregulation enrolled expression Fever functional gene cluster Health Hierarchical hyperinflammatory state immune dysregulation Inflammatory Influenza Kawasaki disease mechanisms MHC class neutrophil neutrophil activation neutrophilic nuclei occur overactivation overlapping Patient performed Potential treatment reduction representing SARS-CoV-2 Sequence Read Archive severe COVID-19 Single-cell RNA sequencing single-cell RNA sequencing. syndrome target Treatment [DOI] 10.3389/fimmu.2022.995886 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics bioinformatics. caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Epitope-Evaluator: An interactive web application to study predicted T-cell epitopesArticle Published on 2022-08-262022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] alleles amino acid sequence antigens candidate class Cutoff Delta distribution downloaded epitope Epitopes facilitate histocompatibility complex Interpretation MHC MHC alleles Multiple omicron parameters peptide predict predicted programming Protein protein sequence proteome provide selected spike T-cell epitope T-cell epitopes the SARS-CoV-2 variant Wuhan [DOI] 10.1371/journal.pone.0273577 PMC 바로가기
Database and AI Diagnostic Tools Improve Understanding of Lung Damage, Correlation of Pulmonary Disease and Brain Damage in COVID-19데이터베이스 및 AI 진단 도구는 COVID-19의 폐 손상, 폐 질환 및 뇌 손상의 상관 관계에 대한 이해를 향상시킵니다.Review Published on 2022-08-222022-09-11 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, [키워드] AI diagnostic Algorithm Algorithms applied article artificial intelligence Brain brain damage caused condition coronavirus disease correlation COVID-19 COVID-19 pandemic damage database databases Diagnosis downloaded Early detection EEG EEGs electroencephalogram evaluated Google Scholar healthcare implication increase in lung lung damage Lung disease Lung diseases Patient pulmonary pulmonary disease pulmonary disease. recent resource Respiratory system SARS-CoV-2 searched shown systematic review the disease understanding [DOI] 10.3390/s22166312 PMC 바로가기 [Article Type] Review
SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samplesSARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.Article Published on 2022-08-082022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while [DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Analysis analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article